Mineralocorticoid Receptor and Aldosterone: Interaction Between NR3C2 Genetic Variants, Sex, and Age in a Mixed Cohort
Authors' conclusion
Our study highlights the significance of the NR3C2 genetic variation and its interplay with age, sex, and race in aldosterone activation. The findings point toward an estrogen-modulating effect on MR activation, particularly in women, underlining the role of aldosterone dysregulation in hypertension development. This insight advances our comprehension of hypertension's complexities and opens avenues for personalized interventions.
Study context
- Population
- 720 Caucasians and 145 Africans from the HyperPATH cohort
- Comparison
- rs4835490 genotypes
- Outcome
- Plasma aldosterone
Main finding
As reported in the abstract
Plasma aldosterone, liberal salt, European ancestry
P = 0.0002
Further findings
Aldosterone activation through posture and urinary excretion
- Association of rs4835490 with posture aldosterone activation
- P = 0.025
- Association of rs4835490 with urinary aldosterone excretion
- P = 0.0122
Interactions with race, sex and age
- Caucasian females <50 years with AA genotype had higher plasma, urine and posture aldosterone than females >50 years
- No such age-dependent interactions in the African cohort
Original publication
Mineralocorticoid Receptor and Aldosterone: Interaction Between NR3C2 Genetic Variants, Sex, and Age in a Mixed Cohort. J Clin Endocrinol Metab. Published 4 March 2024. doi:10.
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