Mild Hyponatremia Is Not Associated With Degradation of Trabecular Bone Microarchitecture Despite Bone Mass Loss
Authors' conclusion
Hyponatremia, at least in mild forms, is not associated with a degradation of trabecular microarchitecture, assessed noninvasively by TBS. An independent association between hyponatremia and loss of bone mass is confirmed, particularly at the total hip.
Study context
- Population
- Subjects aged ≥50 years, National Health and Nutrition Examination Survey 2005–2008 cycles with trabecular bone score (TBS) measurement
- Participants
- 4,204 subjects
- Exposure
- Hyponatremia vs normonatremia
- Hyponatremicn = 163
- Normonatremicn = 4,041reference
- Outcome
- TBS values and BMD T-scores at lumbar spine, total hip and femoral neck
Methodological detailspopulation-based, NHANES 2005-2008 cycles
- Population-based
- NHANES 2005-2008 cycles
Main finding
As reported in the abstract
TBS
- No association between hyponatremia and TBS after adjustment
- P = .346
Observational data: associations, not effects.
Further findings
- Bone mineral density (BMD) T-score at total hip — Hyponatremia independent predictor of lower total hip BMD T-score after adjustment for confounders · lower with Hyponatremic; univariate
- β = −0.20, 95% CI [−0.39, −0.02], P = .029 · P < 0.001
- BMD T-score at femoral neck — Significance lost after adjustment · lower with Hyponatremic; univariate
- P = 0.308 · P = 0.004
- BMD T-score at lumbar spine — No association between hyponatremia and lumbar spine BMD after adjustment · no difference; univariate
- P = 0.236 · P = 0.772
Original publication
Mild Hyponatremia Is Not Associated With Degradation of Trabecular Bone Microarchitecture Despite Bone Mass Loss. J Clin Endocrinol Metab. Published 12 April 2024. doi:10.
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