Ultrashort echo time MRI detects significantly lower collagen but higher pore water in the tibial cortex of female patients with osteopenia and osteoporosis
Authors' conclusion
MMF, BWPD, and MMPD were significantly lower in OPo patients than in the young group, whereas T1, TWPD, and PWPD were significantly higher in OPo patients.
Study context
- Population
- Female patients with osteopenia or osteoporosis (postmenopausal, >55 yr) and young female participants; tibial shaft UTE-MRI
- Participants
- 14 / 31 / 31
- Exposure
- Osteopenia (OPe) vs OPo vs Young
- OPen = 14
- OPon = 31
- Youngn = 31reference
- Outcome
- Water and collagen contents (T1, MMF, TWPD, BWPD, PWPD, MMPD) in tibial cortical bone
Methodological detailsclinical 3T scanner, knee coil
- Clinical 3T scanner
- Knee coil
Main finding
As reported in the abstract
UTE-MRI biomarkers of tibial cortex
- OPo vs Young · lower with OPo
- average percentage difference in MMF 41.9 %
- OPo vs Young
- average percentage difference in PWPD 103.5 %
- OPo vs Young · lower with OPo
- average percentage difference in MMPD 64.0 %
- OPe vs Young · significantly higher with OPe
- average difference in PWPD 50.7 %
- OPe vs Young · significantly lower with OPe
- average difference in BWPD 16.4 %
- OPo vs OPe · significantly lower with OPo
- difference in MMF 27 %
Observational data: associations, not effects.
Further findings
Spearman correlation of TH DXA T-score with UTE-MRI results (OPe and OPo only)
- Correlation of DXA T-score with PWPD
- R = 0.55
- Correlation of DXA T-score with MMF
- R = 0.56
- T1, MMF, TWPD, PWPD and MMPD significantly correlated with TH DXA T-scores
- T-scores provided by the patients
Original publication
Ultrashort echo time MRI detects significantly lower collagen but higher pore water in the tibial cortex of female patients with osteopenia and osteoporosis. J Bone Miner Res. Published 9 April 2024. doi:10.
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