MicroRNA biomarkers target genes and pathways associated with type 2 diabetes
Authors' conclusion
These findings show that miRNA predictors of incident type 2 diabetes target mRNAs and pathways known to underlie risk for type 2 diabetes. Future studies should evaluate miRNAs as potential therapeutic targets for preventing and treating type 2 diabetes.
Study context
- Population
- Five miRNAs predicting incident T2D, previously identified in the Diabetes Prevention Program study
- Outcome
- mRNAs and pathways targeted by the five predictor miRNAs
Methodological detailsbioinformatic analysis, experimentally validated targets from miRTarBase version 8.0, Kyoto Encyclopedia of Genes and Genomes (KEGG) pathway overrepresentation
- Bioinformatic analysis
- Experimentally validated targets from miRTarBase version 8.0
- KEGG pathway overrepresentation
Main finding
As reported in the abstract
Pathways targeted
167
mRNAs targeted
122
Targeted pathways with known associations with T2D (Insulin signaling, Insulin resistance, Diabetic cardiomyopathy, T2D, AGE-RAGE signaling in diabetic complications, HIF-1, TGF-beta, PI3K/Akt and Adipocytokine signaling)
9
Original publication
MicroRNA biomarkers target genes and pathways associated with type 2 diabetes. Diabetes Res Clin Pract. Published 4 August 2023. doi:10.
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