A Metabolomics Study of Cardiac Dysfunction in Hyperglycemia: Findings From the Atherosclerosis Risk in Communities (ARIC) Study and the Hispanic Community Health Study/Study of Latinos (HCHS/SOL)
Authors' conclusion
Metabolites known for microvascular complications were associated with cardiac dysfunction in hyperglycemic individuals but not among their euglycemic counterparts, supporting the premise that microvascular dysfunction contributes to HF pathogenesis in diabetes.
Study context
- Population
- Heart failure (HF)-free participants of ARIC visit 5, 2011–2013; replication in HCHS/SOLARIC visit 5 · replication in HCHS/SOL 5,167
- Participants
- 2,492 participants
- Exposure
- Metabolites associated with cardiac dysfunction in hyperglycemic vs euglycemic individuals
- Hyperglycemicn = 1,297
- Euglycemicn = 1,195
- Outcome
- Subclinical cardiac dysfunction (echocardiographic abnormalities: LV hypertrophy, systolic or diastolic dysfunction; or elevated NT-proBNP or troponin T) associated with 790 metabolites
Methodological detailsreplication cohort (HCHS/SOL)
- Replication cohort (HCHS/SOL)
Main finding
As reported in the abstract
Metabolites associated with cardiac dysfunction
- Hyperglycemic: microvascular disease-related metabolites (e.g., pseudouridine, N6-carbamoylthreonyladenosine, N6-acetyllysine, N2,N5-diacetylornithine) associated with cardiac dysfunction
- Euglycemic: carbohydrate and cofactor-derived metabolites (e.g., gulonate, erythrocyte) associated with cardiac dysfunction
Observational data: associations, not effects.
Further findings
Prospective association of cardiac dysfunction-related metabolites with HF risk · follow-up 7.5 years
- Cardiac dysfunction-related metabolites were prospectively associated with HF risk in the two glycemic groups
- Cox regression adjusted for clinical risk factors
Replication in HCHS/SOL
- HCHS/SOL results were consistent with those from ARIC
Original publication
A Metabolomics Study of Cardiac Dysfunction in Hyperglycemia: Findings From the Atherosclerosis Risk in Communities (ARIC) Study and the Hispanic Community Health Study/Study of Latinos (HCHS/SOL). Diabetes Care. Published 29 July 2025. doi:10.
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