Longitudinal Metabolic Risk Factors Are Associated With Microvascular Complications
Authors' conclusion
AUCs of longitudinal metabolic risk factors, but not slopes, were associated with microvascular complications.
Study context
- Population
- Participants with and without diabetes in the Atherosclerosis Risk in Communities Study; mean age 52.3, 57.1% female, 21.0% with diabetes
- Comparison
- Longitudinal metabolic summaries vs baseline metabolic risk factors
- Primary endpoint
- Microvascular complications: CKD (eGFR), peripheral neuropathy (monofilament testing), retinopathy (ETDRS scale)
Methodological detailslongitudinal, 4 metabolic assessments across 11 years
- Longitudinal
- 4 metabolic assessments across 11 years
Primary result
As reported in the abstract
Associations of longitudinal metabolic AUCs with microvascular complications (logistic regression)
- Fasting glucose AUC and Chronic Kidney Disease (CKD)
- 1.09, 1.05-1.15
- Systolic blood pressure (SBP) AUC and CKD
- 1.27, 1.19-1.36
- Triglyceride AUC and Peripheral Neuropathy (PN)
- 1.14, 1.04-1.25
- Waist AUC and PN
- 1.11, 1.07-1.15
- Fasting glucose AUC and Retinopathy (RN)
- 1.13, 1.04-1.22
Further findings
Discrimination (AUROC) of longitudinal summaries vs cross-sectional metabolic assessments
- Improvement in AUROC
- 0.001-0.01
Original publication
Longitudinal Metabolic Risk Factors Are Associated With Microvascular Complications. Diabetes Obes Metab. Published 13 September 2026. doi:10.
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