Metabolomic evaluation of air pollution-related bone damage and potential mediation in Women’s Health Initiative participants
Authors' conclusion
This is the first study suggesting phospholipids may partially mediate air pollution-related bone damage in postmenopausal women.
Study context
- Population
- Postmenopausal women, Women's Health Initiative (WHI) participants with plasma samples; BMD by DXA at enrollment and Y1, Y3, Y6, Y9
- Outcome
- Air pollutants, metabolites and BMD
Methodological detailsmultivariable-adjusted linear mixed models, pathway analyses, mediation modeling
- Multivariable-adjusted linear mixed models
- Pathway analyses
- Mediation modeling
Main finding
As reported in the abstract
- Partial potential mediation of C38:4 phosphatidylethanolamine (PE) in the association between 1-yr average nitrogen oxide (NO) and LS BMD
- p-value: .032
Observational data: associations, not effects.
Original publication
Metabolomic evaluation of air pollution-related bone damage and potential mediation in Women’s Health Initiative participants. J Bone Miner Res. Published 24 April 2025. doi:10.
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