Metabolically healthy obesity and risks of cardiovascular disease and all-cause mortality, a matched cohort study: the Shizuoka study
Authors' conclusion
Obesity, when accompanied by a healthy metabolic profile, did not increase the risk of cardiovascular outcomes and all-cause mortality.
Study context
- Population
- Individuals aged <65 years in a Japanese health insurance dataset with annual health checkup data (Shizuoka study)matched cohort
- Participants
- 168,699 individuals
- Exposure
- Metabolically healthy obesity vs non-obesity
- Metabolically healthy obesityn = 8,644
- Non-obesityn = 8,644reference
- Outcome
- Incidence rates of stroke, MI and all-cause mortality
Methodological detailsclinical profile-matched, health insurance dataset with annual health checkup data
- Clinical profile-matched
- Health insurance dataset with annual health checkup data
Main finding
As reported in the abstract
Stroke, MI and all-cause mortality incidence rates
| Group | Value | MI incidence rate | All-cause mortality incidence rate |
|---|---|---|---|
| Metabolically healthy obesity | 9.2 per 10,000 person-years | 3.7 | 26.6 |
| Non-obesity | 10.5 | 3.1 | 23.2 |
Value
Metabolically healthy obesity9.2 per 10,000 person-years
Non-obesity10.5
MI incidence rate
Metabolically healthy obesity3.7
Non-obesity3.1
All-cause mortality incidence rate
Metabolically healthy obesity26.6
Non-obesity23.2
- Metabolically healthy obesity vs Non-obesity: log-rank test p = 0.595 — per_group value = stroke incidence rate
- Metabolically healthy obesity vs Non-obesity: P = 0.613
- Metabolically healthy obesity vs Non-obesity: P = 0.304
Observational data: associations, not effects.
Further findings
Metabolically unhealthy obesity vs non-obesity (n = 10,965 each)
- Lack of association also observed
Metabolic profiles · 5.6-year follow-up
- Negligibly worse metabolic profiles with metabolically healthy obesity than non-obesity
Original publication
Metabolically healthy obesity and risks of cardiovascular disease and all-cause mortality, a matched cohort study: the Shizuoka study. Int J Obes (Lond). Published 18 May 2024. doi:10.
Composed by AI from the published abstract and checked against it. How Briefs are made →