Metabolic remission precedes possible weight regain after gastric bypass surgery
Authors' conclusion
Remission of the metabolic state was observed prior to notable weight regain. Further and more long-term studies are required to assess whether the extent of metabolic remission predicts future weight regain and glycemic deterioration.
Study context
- Population
- Patients undergoing RYGB, sampled before RYGB and at 2, 12 and 60 months post RYGB
- Participants
- 148 patients
- Outcome
- Whether, when and to what extent metabolic remission occurs (fasting plasma metabolite and lipid profiles)
- Follow-up
- Before RYGB and at 2, 12, and 60 months post RYGB
Methodological detailslongitudinal
- Longitudinal
Main finding
As reported in the abstract
- Vast majority of changes in metabolite levels occurred during the first 2 months post RYGB
- Thereafter the metabolome started to return toward the presurgical state
- Close-to-presurgical metabolome observed when patients reached their lowest weight and glucose level
- Lipids with longer acyl chains and higher unsaturation altered more than shorter, more saturated lipids, suggesting systematic, reversible lipid remodeling
Observational data: associations, not effects.
Original publication
Metabolic remission precedes possible weight regain after gastric bypass surgery. Obesity (Silver Spring). Published 16 August 2023. doi:10.
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