Lipids & metabolic liver disease
Metabolic Complications and Ultrasound‐Detected Liver Abnormalities in Paediatric Patients With Duchenne Muscular Dystrophy
Authors' conclusion
Metabolic complexity in DMD calls for early targeted care; understanding the dystrophin role may be crucial.
Study context
- Population
- Paediatric patients with Duchenne muscular dystrophy (DMD); mean age 11.2 ± 4.4 years, 72 ambulant, 78% on steroid therapy (mean 52.6 ± 46.7 months)
- Participants
- 131 patients
- Outcome
- Metabolic complications: liver US abnormalities and abnormal biochemical markers in relation to disease progression
Main finding
As reported in the abstract
Liver US abnormalities
Hepatomegaly
56%
Steatosis
24%
Observational data: associations, not effects.
Further findings
Increased BMI z-scores
- Increased BMI z-scores
- 41%
- Obese
- 19%
- Overweight
- 22%
- Age-related variation
- χ2 = 15.68, p = 0.0035
Biochemical markers
- Dyslipidemia
- 81%
- Insulin resistance
- 13.9%
- Insulin levels increased with age
Original publication
Metabolic Complications and Ultrasound‐Detected Liver Abnormalities in Paediatric Patients With Duchenne Muscular Dystrophy. Pediatr Obes. Published 29 March 2026. doi:10.
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