Lipids & metabolic liver disease
Body Roundness Index and All‐Cause Mortality in Metabolic Dysfunction‐Associated Steatotic Liver Disease: A Dual‐Cohort Study
Authors' conclusion
BRI demonstrates a significant linear association with mortality in the US MASLD population. In the Chinese elderly MASLD population, statistical power was insufficient to draw definitive conclusions about BRI-mortality associations. The observed between-cohort heterogeneity likely reflects multiple factors, including differences in age structure, obesity phenotype, mortality ascertainment methods, and potentially genuine population-specific characteristics. These findings underscore the importance of population-specific validation before extrapolating Western-derived BRI thresholds to Asian populations.
Study context
- Population
- Adults with MASLD in two nationally representative cohorts: NHANES (US) and CHARLS (China)
- Participants
- 7,723 vs 6,553
- Exposure
- Body roundness index (BRI) and all-cause mortality, NHANES vs CHARLS
- NHANESn = 7,723
- CHARLSn = 6,553
- Outcome
- All-cause mortality
Methodological detailsdual-cohort, two nationally representative cohorts, Cox proportional hazards regression with restricted cubic splines
- Dual-cohort
- Two nationally representative cohorts
- Cox proportional hazards regression with restricted cubic splines
Main finding
As reported in the abstract
Per SD BRI, as printed
- Between-cohort heterogeneity substantial (I2, p = 0.023)
- 80.7%
Observational data: associations, not effects.
Further findings
Triglyceride-glucose (TyG) index attenuation of BRI-mortality association (NHANES)
- Statistical attenuation by TyG index
- 33.8% (95% CI, 18.2%-52.4%)
Original publication
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