Medication prescribing and pregnancy-related risk factors for women with type 2 diabetes of reproductive age within primary care: a cross-sectional investigation for the PREPARED study
Authors' conclusion
Women with type 2 diabetes have suboptimal contraceptive provision despite multiple exposures to medications not recommended for pregnancy. Regular assessment of contraceptive use, reproductive intentions, and medication review is urgently needed in primary care settings to minimize pregnancy-related risks.
Study context
- Population
- Women aged 18–45 years with T2D in participating UK general practices
- Participants
- 725 women
- Outcome
- Pregnancy-related risk factors and medication exposures (medications not recommended for pregnancy)
Methodological detailsprimary care records, UK general practices
- Primary care records
- UK general practices
Main finding
As reported in the abstract
- Diabetes medications prescribed
- 65%, n=471
- Statins prescribed
- 20%, n=145
- Took ≥3 medications
- 37% (n=268)
- Took medications not recommended for pregnancy
- a third (n=269)
- Not prescribed contraception
- 89%, n=646
- Polypharmacy associated with use of medications not recommended for pregnancy (multivariable logistic regression), OR
- 3.49 (95% CI 2.88 to 4.30)
- Age associated with use of medications not recommended for pregnancy (multivariable logistic regression), OR
- 1.04 (95% CI 1.00 to 1.09)
Observational data: associations, not effects.
Further findings
Factors associated with use of medications not recommended for pregnancy (multivariable logistic regression)
| OR (95% CI) | ||
|---|---|---|
| PolypharmacyMultivariable logistic regression | 3.49 (2.88–4.30) | |
| AgeMultivariable logistic regression | 1.04 (1.00–1.09) | |
| 0.20.5125Odds ratio (log scale) |
Original publication
Medication prescribing and pregnancy-related risk factors for women with type 2 diabetes of reproductive age within primary care: a cross-sectional investigation for the PREPARED study. BMJ Open Diabetes Res Care. Published 5 March 2025. doi:10.
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