Maternal obesity and ancestry distance in influencing birth outcomes
Authors' conclusion
Interplays between maternal GD from Amerindigenous and East Asian references and pre-pregnancy obesity influence placental weight and risk of LGA. The results underline that consideration of maternal obesity in the context of GD from multiple ancestries and SES may facilitate interventions that will minimize adverse pregnancy outcomes.
Study context
- Population
- Multi-ancestral pregnant women, NICHD Fetal Growth Studies-Singletons cohort; Genetic distance (GD) from four ancestral reference populations
- Participants
- 1,810 women
- Exposure
- Maternal genetic distance (GD) quintiles and their interaction with pre-pregnancy obesity
- Outcome
- Birthweight, placental weight and large for gestational age (LGA) in relation to GD and its interaction with maternal obesity
Methodological detailsmulti-ancestral
- Multi-ancestral
Main finding
As reported in the abstract
Interaction of GD and maternal obesity with placental weight and LGA
Difference in placental weight, g (95% CI)P value
Third Amerindigenous GD quintile × obesityvs First GD quintilelarger placental weight with the third Amerindigenous GD quintile × obesity
198(51–345)
P = 0.009Odds ratio (95% CI)P value
East Asian fourth GD quintile × obesityvs First GD quintile86.0% lower odds of LGA
0.14(0.02–74)
P = 0.031Observational data: associations, not effects.
Parts of this Brief are withheld: the automatic checks could not confirm them against the abstract.
Original publication
Maternal obesity and ancestry distance in influencing birth outcomes. Int J Obes (Lond). Published 12 April 2025. doi:10.
Composed by AI from the published abstract and checked against it. How Briefs are made →