Maternal Diabetes in Youth-Onset Type 2 Diabetes Is Associated With Progressive Dysglycemia and Risk of Complications
Authors' conclusion
Maternal diabetes, regardless of whether diagnosed during vs after pregnancy, is associated with worse glycemic control, glomerular hyperfiltration, and reduced heart rate variability in youth with T2D in TODAY. The strong associations of diabetes outcomes with maternal diabetes suggest a possible role for in utero programming.
Study context
- Population
- Youth aged 10 to 17 years with T2D, 15 US centers, TODAY and TODAY2 studies
- Participants
- 301 / 218 / 102 / 352 / 167
- Comparison
- Maternal or paternal diabetes vs no parental diabetes
- Nevern = 301reference
- Before or during pregnancyn = 218
- After pregnancyn = 102
- No diabetesn = 352reference
- Paternal diabetesn = 167
Methodological detailsmulticentre, longitudinal follow-up up to 12 years
- Multicentre
- Longitudinal follow-up up to 12 years
Primary result
As reported in the abstract
Loss of glycemic control (HbA1c ≥8% for >6 months)
- Maternal, but not paternal, diabetes associated with loss of glycemic control over time
- P = .001
Further findings
Glomerular hyperfiltration · up to 12 years
- Maternal, but not paternal, diabetes associated with increased risk
- P = 0.01
Low heart rate variability · up to 12 years
- Maternal, but not paternal, diabetes associated with increased risk
- P = 0.006
Timing of maternal diabetes
- Maternal diabetes during vs after pregnancy had similar effects on outcomes
- Effects largely independent of age, sex, race/ethnicity and household income
Parts of this Brief are withheld: the automatic checks could not confirm them against the abstract.
Original publication
Maternal Diabetes in Youth-Onset Type 2 Diabetes Is Associated With Progressive Dysglycemia and Risk of Complications. J Clin Endocrinol Metab. Published 30 November 2022. doi:10.
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