Chronic kidney disease begets heart failure and vice versa: temporal associations between heart failure events in relation to incident chronic kidney disease in type 2 diabetes
Authors' conclusion
Cardiorenal complications are common and are associated with high mortality risk among patients with new-onset T2DM. Close surveillance of these dual complications is crucial to reduce the burden of disease.
Study context
- Population
- Patients aged ≥18 years with new-onset T2D, without renal disease or heart failure (HF) at baseline, Clinical Data Analysis Reporting System 2000–2015; median age 66 years, 45.7% womenmedian follow-up 7.5 years
- Participants
- 102,488 patients
- Exposure
- Incident chronic kidney disease (CKD) vs incident HF in new-onset T2D
- CKDn = 14,798
- HFn = 9,258
- Outcome
- Incident CKD and HF
- Follow-up
- Median 7.5 years
Methodological detailsterritory-wide
- Territory-wide
Main finding
As reported in the abstract
| Group | Value | Crude incidence /1000 person-years | With HF | With CKD |
|---|---|---|---|---|
| CKD | 14.4% | 17.6 (95% CI 17.3-17.9) | 21.7% | |
| HF | 9.0% | 10.6 (95% CI 10.4-10.9) | 34.6% |
Value
CKD14.4%
HF9.0%
Crude incidence /1000 person-years
CKD17.6 (95% CI 17.3-17.9)
HF10.6 (95% CI 10.4-10.9)
With HF
CKD21.7%
HF— not stated in the abstract
With CKD
CKD— not stated in the abstract
HF34.6%
Observational data: associations, not effects.
Further findings
Median time from baseline to incident CKD or HF
Time to incident HF after CKD diagnosis vs incident CKD after HF diagnosis · CKD: time to HF after CKD; HF: time to CKD after HF
P < 0.001
Median time from baseline to incident CKD or HF
- Did not differ
All-cause mortality
- Either condition vs CKD/HF-free: hazard of death
- three-fold
- Concomitant HF and CKD: adjusted hazard of mortality
- six to seven-fold
- Incident HF associated with higher adjusted mortality than incident CKD
Original publication
Chronic kidney disease begets heart failure and vice versa: temporal associations between heart failure events in relation to incident chronic kidney disease in type 2 diabetes. Diabetes Obes Metab. Published 29 November 2022. doi:10.
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