Cardiometabolic profile and cardiorenal complications across BMI categories in type 2 diabetes: A nationwide real-world analysis of over 500,000 patients
Authors' conclusion
In this large real-world T2D cohort, the lower crude prevalence of cardiovascular complications in patients with obesity was partly explained by confounding factors. Obesity was associated with a higher prevalence of CKD and HF
Study context
- Population
- Adults with T2D attending 296 Italian diabetes centers in 2023
- Participants
- 519,005 adults296 centers
- Exposure
- BMI categories
- Outcome
- Association between BMI category and coronary artery disease, HF, cerebrovascular disease, peripheral artery disease and CKD
Methodological detailsnationwide, multicentre, real-world
- Nationwide
- Multicentre
- Real-world
Main finding
As reported in the abstract
Cardiorenal complications by BMI category (adjusted)
Prevalence ratio
1.13
P < 0.001
Chronic kidney disease (CKD), after adjustment
Prevalence ratio
1.41
P < 0.001
Heart failure (HF), after adjustment
Observational data: associations, not effects.
Further findings
Prevalence of BMI categories · 2023
Clinical profile across BMI categories
- Despite similar HbA1c levels, cardiometabolic risk factors progressively worsened across BMI categories
- Patients with obesity were younger, with shorter diabetes duration and lower crude rates of most cardiovascular complications
Original publication
Cardiometabolic profile and cardiorenal complications across BMI categories in type 2 diabetes: A nationwide real-world analysis of over 500,000 patients. Diabetes Res Clin Pract. Published 29 July 2026. doi:10.
Composed by AI from the published abstract and checked against it. How Briefs are made →