Marked Increases in Continuous Glucose Monitor-Detected Hypoglycemia During a Seven-Day Water-Only Fast in Healthy Men and Women
Authors' conclusion
This research demonstrated considerable hypoglycemia exposure occurs without symptoms in heathy men and women who undertake multiday fasting.
Study context
- Population
- Healthy adults (seven men; age 29.7 ± 6.1 years; BMI 25.0 ± 3.3 kg/m²)
- Participants
- 12 adults
- Outcome
- Distribution of CGM interstitial glucose / hypoglycemia exposure (time <70 mg/dL)
Main finding
As reported in the abstract
Time <70 mg/dL · baseline to day 5
- Time <70 mg/dL at baseline (mean ± SD)
- 3.0% ± 7.1%
- Time <70 mg/dL by day 5 (mean ± SD)
- 66.0% ± 25.7%
- Change from baseline to day 5
- P < .001
Observational data: associations, not effects.
Further findings
Minimum daily glucose · baseline to day 5
- Minimum daily glucose at baseline
- 76 ± 14 mg/dL
- Minimum daily glucose by day 5
- 50 ± 7 mg/dL
- Change from baseline to day 5
- P < 0.001
Glycemia with performance tests (day 6) and OGTT (day 7)
- The performance tests and the OGTT markedly increased glycemia
Safety
- No symptoms of hypoglycemia were reported
Original publication
Marked Increases in Continuous Glucose Monitor-Detected Hypoglycemia During a Seven-Day Water-Only Fast in Healthy Men and Women. J Diabetes Sci Technol. Published 22 February 2026. doi:10.
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