Lower-than-normal glycemic levels to achieve optimal reduction of diabetes risk among individuals with prediabetes: A prospective cohort study
Authors' conclusion
Given that lower-than-normal glycemic levels were plausible for optimal risk reduction of diabetes, stringent glycemic management could be beneficial for diabetes prevention among individuals with prediabetes.
Study context
- Population
- Individuals with prediabetes (9903) and normoglycemia (16,902) from a prospective cohort attending health check-ups, 2006–2017
- Exposure
- Lower vs higher baseline fasting and postprandial glucose categories in prediabetes
- Outcome
- Incident diabetes
Main finding
As reported in the abstract
Incident diabetes in prediabetes
Hazard ratio (95% CI)
FG <5.0vs FG 5.6-6.9
0.34(0.27–0.42)
PPG <6.7vs PPG 7.8-11.0
0.47(0.41–0.54)
Observational data: associations, not effects.
Further findings
Diabetes incidence by fasting/postprandial glucose category
Per 1000 person-years
- Prediabetes with fasting/postprandial glucose <5.0/<6.7 mmol/L
- 6.4 (4.7-8.8)
- Normoglycemia with fasting/postprandial glucose 5.0-5.5/6.7-7.7 mmol/L
- 5.8 (4.2-8.0)
Original publication
Lower-than-normal glycemic levels to achieve optimal reduction of diabetes risk among individuals with prediabetes: A prospective cohort study. Diabetes Res Clin Pract. Published 3 February 2023. doi:10.
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