Cumulative muscle strength and risk of diabetes: A prospective cohort study with mediation analysis
Authors' conclusion
Higher cumulative muscle strength was associated with lower risk of diabetes and better cardiometabolic health in middle-aged and older Chinese adults.
Study context
- Population
- Middle-aged and older Chinese adults without diabetes with 3 repeated measurements of muscle strength over 4 years3,731 grip
- Exposure
- Per 1 SD change in 4-year cumulative muscle strength
- Outcome
- Diabetes
Methodological detailsmediation analysis
- Mediation analysis
Main finding
As reported in the abstract
OR per 1 SD increment in cumulative grip strength, multivariable-adjusted
0.79
OR per 1 SD decrement in cumulative chair-rising time, multivariable-adjusted
0.89
Observational data: associations, not effects.
Further findings
Mediation by cumulative systolic blood pressure
- Proportion mediated, cumulative grip strength–diabetes association
- 10.8%
- Proportion mediated, cumulative chair-rising time–diabetes association
- 14.2%
Cardiometabolic correlates
- Cumulative grip strength correlated inversely with blood pressure, glycemia and inflammation
Original publication
Cumulative muscle strength and risk of diabetes: A prospective cohort study with mediation analysis. Diabetes Res Clin Pract. Published 3 February 2023. doi:10.
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