Low levels of soluble neuropilin‐1 were associated with depression in adults with newly diagnosed type 2 diabetes
Authors' conclusion
Low sNRP-1 (<226 ng/mL) was associated with depression in all patients with newly diagnosed T2D. In younger patients (<60 years), depression, pre-existing myocardial infarction and younger age were associated with low sNRP-1. In older patients, only depression and younger age were associated with low sNRP-1.
Study context
- Population
- Adults with serologically confirmed newly diagnosed T2D (18–94 years; <60 years 38%)
- Participants
- 837 adults
- Exposure
- Depressed vs non-depressed patients
- Depressedn = 119
- Non-depressedn = 718reference
- Outcome
- Association between sNRP-1 (low <226 ng/mL) and depression
Methodological detailsmulticentre
- Multicentre
Main finding
As reported in the abstract
P < 0.001
- Low sNRP-1 independently associated with depression (n = 736), aOR
- 3.3, p < 0.001
Observational data: associations, not effects.
Further findings
Characteristics in depressed vs non-depressed
- Anxiety, depressed vs non-depressed (p < 0.001)
- 64% vs. 14%
- Antidepressants, depressed vs non-depressed (p < 0.001)
- 36% vs. 14%
- Physical inactivity, depressed vs non-depressed (p = 0.006)
- 42% vs. 29%
- Smoking, depressed vs non-depressed (p = 0.018)
- 20% vs. 12%
- Higher BMI in depressed
- P = 0.002
Other factors independently associated with depression (n = 736)
- Anxiety, aOR
- 11.7, p < 0.001
- BMI (per kg/m²), aOR
- 1.1, p = 0.016
- Physical inactivity, aOR
- 1.8, p = 0.018
Factors independently associated with low sNRP-1, younger patients (<60 years; n = 288)
- Depression, aOR
- 3.3, p < 0.001
- MI, aOR
- 3.8, p = 0.039
- Younger age (per year), aOR
- 0.97, p = 0.043
Factors independently associated with low sNRP-1, older patients (n = 521)
- Depression, aOR
- 3.1, p < 0.001
- Younger age
- 0.97, p = 0.030
Original publication
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