Longitudinal trends in glycated hemoglobin during and after tuberculosis treatment
Authors' conclusion
Incident TB promotes transient glucose elevation but was not conclusively shown to promote chronic dysglycemia. Rising A1C during and after TB treatment may predict unfavorable treatment response in persons presenting with A1C ≥ 6.5 % at the time of TB diagnosis.
Study context
- Population
- Adults with pulmonary TB in Chennai, India2 cohorts combined
- Participants
- 74 / 110 / 244
- Exposure
- Baseline glycemic status: Normoglycemia (NG) vs pre-DM vs DM
- NGn = 74
- pre-DMn = 110
- DMn = 244
- Outcome
- Glycemic status (A1C) during and after TB treatment
- Follow-up
- TB treatment months 3 and 6; 6 and 12 months after TB treatment completion
Methodological detailspooled analysis of two prospective cohort studies
- Pooled analysis of two prospective cohort studies
Main finding
As reported in the abstract
TB treatment months 3 and 6; 6 and 12 months after TB treatment completion
Baseline DM participants shifted to pre-DM or NG levels of A1c (A1C)
16.7%
Observational data: associations, not effects.
Original publication
Longitudinal trends in glycated hemoglobin during and after tuberculosis treatment. Diabetes Res Clin Pract. Published 7 January 2023. doi:10.
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