Longitudinal Profiling of Endogenous Steroids in Blood Using the Athlete Biological Passport Approach
Authors' conclusion
Inclusion of T and T/A4 as markers in the Steroidal Module can improve the performance of the ABP to identify T transdermal application, particularly in females.
Study context
- Population
- Elite athletes (n = 823; priors) and clinical trial subjects given T: males (control phase, then patch, then oral T) and females (3 menstrual cycles, 28 days of daily transdermal T in the second month); anti-doping laboratory
- Comparison
- Serum T vs T/A4 as Athlete Biological Passport (ABP) markers for detecting transdermal and oral T administration
- Outcome
- Performance of a longitudinal ABP-based approach for serum T and T/A4
Methodological detailsopen-label administration studies, longitudinal ABP-based approach, priors from 4 years of anti-doping data
- Open-label administration studies
- Longitudinal ABP-based approach
- Priors from 4 years of anti-doping data
Performance
As reported in the abstract
Detection by ABP-based approach at 99% specificity
- Female subjects flagged during transdermal T application
- all
- Female subjects flagged 3 days after treatment
- 44%
- Sensitivity of T for transdermal T application in males (best)
- 74%
Parts of this Brief are withheld: the automatic checks could not confirm them against the abstract.
Original publication
Longitudinal Profiling of Endogenous Steroids in Blood Using the Athlete Biological Passport Approach. J Clin Endocrinol Metab. Published 16 February 2023. doi:10.
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