Fertility in Acromegaly: A Single-Center Experience of Female Patients During Active Disease and After Disease Remission
An erratum to this article was published (J Clin Endocrinol Metab, 16 Sep 2024 ↗)
Authors' conclusion
Gonadal dysfunction and infertility are common in acromegalic women within reproductive age, being directly influenced by disease status and/or duration.
Study context
- Population
- Acromegalic women with disease onset within reproductive age
- Participants
- 50 women
- Exposure
- Disease onset vs diagnosis vs disease control
- Outcome
- Prevalence of gonadal dysfunction and infertility
- Follow-up
- Disease onset, diagnosis and after disease control
Methodological detailssingle-centre, referral-center
- Single-centre
- Referral-center
Main finding
As reported in the abstract
- Menstrual disturbances at presumed disease onset
- 32%
- Uterine leiomyoma, ovarian cysts and PCOM at disease onset
- 18%, 12%, and 8%
- Infertile at disease onset
- 36.8%
- Menstrual disturbances at diagnosis
- 58.1% (P = .02)
- Uterine leiomyoma at diagnosis
- 39.1% (P = .04)
- Ovarian cysts at diagnosis
- 28.2% (P = .09)
- PCOM at diagnosis
- 13% (P = .55)
- Infertility rate at diagnosis
- 100% (P = .02)
- Menstrual disturbances at disease control slightly decreased vs diagnosis
- P = .09
Observational data: associations, not effects.
Further findings
Menstrual disturbances at diagnosis
- Menstrual disturbances at diagnosis vs onset (P = .02)
- 58.1%
- More prevalent with higher IGF-1 quartiles (Q1 vs Q4)
- P = 0.03
Gynecological US findings at diagnosis
- Uterine leiomyoma (P = .04)
- 39.1%
- Ovarian cysts (P = .09)
- 28.2%
- PCOM (P = .55)
- 13%
- Infertility rate (P = .02)
- 100%
Menstrual disturbances after disease control
- Slightly decreased vs diagnosis
- P = 0.09
- Menstrual disturbances more frequent with active disease >5 years vs control in <5 years
- P = 0.05
- Amenorrhea more frequent with active disease >5 years vs control in <5 years
- P = 0.03
Fertility and pregnancy outcomes after disease control
- Conceived at least once, among patients with pregnancy desire
- 73.3%
- Infertility, significantly decreased vs diagnosis (P = .01)
- 26.7%
- At-term deliveries, preterm deliveries, spontaneous abortions, of 15 pregnancies
- 86.7%, 6.6%, 6.6%
- No neonatal malformations and/or abnormalities were recorded
Original publication
Fertility in Acromegaly: A Single-Center Experience of Female Patients During Active Disease and After Disease Remission. J Clin Endocrinol Metab. Published 15 February 2023. doi:10.
Composed by AI from the published abstract and checked against it. How Briefs are made →