Longitudinal metabolomics of increasing body-mass index and waist-hip ratio reveals two dynamic patterns of obesity pandemic
Authors' conclusion
Age-associated weight variation in adults between 24 and 49 manifests as temporal divergence in BMI and uniform progression of WHR across metabolic health strata.
Study context
- Population
- Finnish population-based datasets: FINRISK (ages 25–74), NFBC1966 birth cohort (age 31 and 46) for subgrouping; Young Finns Study (ages 24–39 at baseline, 10 years follow-up, three visits) for trajectories
- Exposure
- Four metabolic subgroups
- Outcome
- BMI, WHR and metabolic trajectories by subgroup
- Follow-up
- Age 24 to 49
Methodological detailspopulation-based, self-organizing map subgrouping, trajectory modelling by linear regression, self-organizing map (SOM) created from 174 metabolic measures; expert committee defined four subgroups by visual inspection
- Population-based
- Self-organizing map subgrouping
- Trajectory modelling by linear regression
- SOM created from 174 metabolic measures; expert committee defined four subgroups by visual inspection
Main finding
As reported in the abstract
- Fasting insulin difference at age 49, TG-rich vs TG-poor
- three-fold
Observational data: associations, not effects.
Original publication
Longitudinal metabolomics of increasing body-mass index and waist-hip ratio reveals two dynamic patterns of obesity pandemic. Int J Obes (Lond). Published 23 February 2023. doi:10.
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