Longitudinal Changes in Sex Hormones in a Population of Older Community-dwelling Men
Authors' conclusion
In old men, there was a broad range of total testosterone levels, and a significant fraction were in a range considered hypogonadal. In longitudinal analyses, although there was considerable interindividual variation, gradual declines in mean total testosterone continued in the 8th through 10th decades of life.
Study context
- Population
- Community-dwelling men aged 78 to 97 years in the Osteoporotic Fractures in Men study215 longitudinal
- Participants
- 477 men
- Outcome
- SH concentrations in older men and long-term changes
Methodological detailscross-sectional and longitudinal analyses, community-dwelling
- Cross-sectional and longitudinal analyses
- Community-dwelling
Main finding
As reported in the abstract
Total testosterone (cross-sectional)
Mean total testosterone
413.9 ± 180.0
Total testosterone <275 ng/dL
21.4%
Directly measured free testosterone low (<6.6 ng/dL)
37.6%
Observational data: associations, not effects.
Further findings
Longitudinal change in sex hormones (SHs) · 14.0 ± 0.65 years earlier
- Total testosterone >275 ng/dL at baseline that decreased to <275 ng/dL
- 20.5%
- Average total testosterone, estradiol and estrone decreased, sex hormone binding globulin (SHBG) increased; changes highly variable
- n = 215
Original publication
Longitudinal Changes in Sex Hormones in a Population of Older Community-dwelling Men. J Clin Endocrinol Metab. Published 11 December 2025. doi:10.
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