Longitudinal changes in remnant cholesterol and the risk of cardiovascular disease
Authors' conclusion
The stable high RC was associated with a higher risk of CVD. Maintaining optional RC levels could reduce the lifetime risk of CVD and prolong the year of life free from CVD.
Study context
- Population
- Participants of the Kailuan study; Remnant cholesterol (RC) cutoffs equivalent to LDL-C 2.6 mmol/L percentiles (0.52 mmol/L in 2006, 0.51 mmol/L in 2008)
- Exposure
- High stable vs low stable remnant cholesterol
- Outcome
- Cardiovascular disease (CVD) and its subtypes (MI and stroke)
Methodological detailsKailuan study, multivariate Cox proportional hazards models
- Kailuan study
- Multivariate Cox proportional hazards models
Main finding
As reported in the abstract
CVD, MI and stroke — RC short-term change analysis
Each group vs low stableEstimate (95% CI)
High stable
HR (CVD) 1.31(1.22–1.41)
High stable
HR (MI) 1.73(1.47–2.03)
High stable
HR (stroke) 1.21(1.12–1.31)
Observational data: associations, not effects.
Further findings
| Outcome | Estimate | |
|---|---|---|
| CVD, MI and stroke — RC long-term change analysis (3 trajectories, 2006–2010)High stablevs Low stable | HR (CVD) 1.34 (95% CI 1.17–1.53) | |
| CVD, MI and stroke — RC long-term change analysis (3 trajectories, 2006–2010)High stablevs Low stable | HR (MI) 1.66 (95% CI 1.24–2.21) | |
| CVD, MI and stroke — RC long-term change analysis (3 trajectories, 2006–2010)High stablevs Low stable | HR (stroke) 1.22 (95% CI 1.05–1.42) | |
| 0.512Ratio (log scale) |
Original publication
Longitudinal changes in remnant cholesterol and the risk of cardiovascular disease. Cardiovasc Diabetol. Published 2 January 2025. doi:10.
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