Longitudinal associations of physical activity with inflammatory markers in US adults with and without type 1 diabetes
Authors' conclusion
Our findings highlight that meeting ≥ 150 mins/week of MVPA is inversely associated with inflammatory markers linked with increased CVD risk.
Study context
- Population
- Individuals with T1D and without DM, Coronary Artery Calcification in T1D (CACTI) cohort; ∼3 years follow-upIndividuals with T1D 563 · without DM 692
- Exposure
- Any moderate-to-vigorous physical activity (MVPA), 1-149 mins/week or ≥150 mins/week vs sedentary
- Outcome
- C-reactive protein (CRP), PAI-1 and fibrinogen
- Follow-up
- ∼ 3 years
Methodological detailsmixed effect models with unstructured covariance structure
- Mixed effect models with unstructured covariance structure
Main finding
As reported in the abstract
% change in fibrinogen
−2.96 %
P = 0.0043
Any MVPA
% change in PAI-1
−11.23 %
P = 0.0007
Any MVPA
Observational data: associations, not effects.
Further findings
| Outcome | % change (%) |
|---|---|
| Fibrinogen, stratified analysis in T1D1-149 mins/week vs Sedentary · T1D; significant | −5.31 |
| Fibrinogen, stratified analysis in T1D≥150 mins/week vs Sedentary · T1D; significant | −3.44 |
| PAI-1 with ≥150 mins/week, stratified analysis≥150 mins/week vs Sedentary · non-DM; significant | −9.11 |
| PAI-1 with ≥150 mins/week, stratified analysis≥150 mins/week vs Sedentary · T1D; significant | −16.96 |
Original publication
Longitudinal associations of physical activity with inflammatory markers in US adults with and without type 1 diabetes. Diabetes Res Clin Pract. Published 25 October 2023. doi:10.
Composed by AI from the published abstract and checked against it. How Briefs are made →