Long-term survival in stroke patients: insights into triglyceride-glucose body mass index from ICU data
Authors' conclusion
In our study, lower TyG-BMI levels in critically ill stroke patients are significantly related to a higher risk of long-term ACM within the context of the United States. This finding suggests the potential of TyG-BMI as a marker for stratifying long-term risk in this patient population. However, it's crucial to note that this association was not observed for short-term ACM, indicating that the utility of TyG-BMI may be more pronounced in long-term outcome prediction. Additionally, our conclusion that TyG-BMI could serve as a reliable indicator for managing and stratifying stroke patients over the long term is preliminary. To confirm our findings and assess the universal applicability of TyG-BMI as a prognostic tool, it is crucial to conduct rigorously designed research across various populations.
Study context
- Population
- Critically ill stroke patients at ICU admission, MIMIC-IV 2.2 database; median age 68 years (IQR 58–78), 55.42% male
- Participants
- 1,707 patients
- Exposure
- Triglyceride Glucose-Body Mass Index (TyG-BMI) tertiles
- Outcome
- ACM at 90 days, 180 days and 1 year
- Follow-up
- 90-day, 180-day, 1-year
Methodological detailsMIMIC-IV 2.2 database, TyG-BMI tertiles
- MIMIC-IV 2.2 database
- TyG-BMI tertiles
Main finding
As reported in the abstract
- Kaplan-Meier (K-M) curves: lower TyG-BMI associated with heightened risk of long-term all-cause mortality (ACM)
- Cox regression: significantly increased risk of long-term ACM in the lowest TyG-BMI tertile
- Restricted cubic splines (RCS): L-shaped correlation between TyG-BMI and long-term ACM
Observational data: associations, not effects.
Secondary outcomes
Short-term ACM (ICU, in-hospital, 30-day)
- No statistically significant differences across the three TyG-BMI groups (K-M)
- RCS: L-shaped correlation between TyG-BMI and short-term ACM
Interaction/subgroup analyses
- No interactions between TyG-BMI and stratified variables, except age
Parts of this Brief are withheld: the automatic checks could not confirm them against the abstract.
Original publication
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