Long-term remission of impaired glucose tolerance in the finnish diabetes prevention study
Authors' conclusion
IGT may be normalised in the long term through weight loss and healthier lifestyles choices.
Study context
- Population
- Participants with impaired glucose tolerance (IGT) in the Finnish Diabetes Prevention Study; median lifestyle intervention 4 years, follow-up up to 18 yearsincluded in analyses
- Participants
- 505 participants
- Primary endpoint
- Remission of IGT, defined as normoglycaemia (FPG < 5.6 mmol/L, 2-h post-load glucose < 7.8 mmol/L, HbA1c < 39 mmol/mol)
Methodological detailslong-term follow-up
- Long-term follow-up
Primary result
As reported in the abstract
Remission of IGT
Remission at least once
32%
Remission at year 1
13%
Remission at year 3
12%
Remission at first post-intervention follow-up visit (median 5 years, range 4 - 8 years)
11%
Further findings
Short-term predictors of remission
- Weight loss, reduced waist circumference, higher fibre and lower saturated fat intake, physical activity, enhanced insulin sensitivity and recovery of insulin secretion predicted remission
Longer-term predictors of remission
- Only insulin secretory and sensitivity indices were associated with remission
Original publication
Long-term remission of impaired glucose tolerance in the finnish diabetes prevention study. Diabetes Res Clin Pract. Published 22 March 2026. doi:10.
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