Long‐term impact of weight loss for people with overweight but not obesity, and with type 2 diabetes: 10‐year outcomes of a randomized trial of gastric band surgery
Authors' conclusion
When compared with medical care, GB surgery achieved greater weight loss and modestly increased the likelihood of diabetes remission. However, it did not improve HbA1c, cardiovascular risk or quality of life.
Study context
- Population
- Adults with T2D who are overweight but not obese, randomized 2009–201141 completed 10-year assessment
- Participants
- 51 adults
- Comparison
- Multidisciplinary diabetes care plus gastric band (GB) surgery vs multidisciplinary diabetes care
- GBn = 21
- Medicaln = 20reference
- Primary endpoint
- Diabetes remission: HbA1c <6.5% (48 mmol/mol) without glucose-lowering medication
- Follow-up
- 10 years
Methodological details10-year follow-up, Discharged to community care after 5 years; reassessed after 10 years
- 10-year follow-up
- Discharged to community care after 5 years; reassessed after 10 years
Primary result
As reported in the abstract
Diabetes remission (HbA1c <6.5% (48 mmol/mol) without glucose-lowering medication)
Relative risk (event the ratio is of not named in abstract)
0.76
95% CI 0.55–0.93
P = 0.048
Events by treatment group
GB
5
events
Medical
0
events
Between GB and Medical
relative risk (event the ratio is of not named in abstract) 0.76 (95% CI 0.55–0.93); P = 0.048
Further findings
Weight loss · 10 years
median difference 4.2 · P = 0.008
Glucose-lowering medications · 10 years
- GB participants used fewer glucose-lowering medications
HbA1c, fasting glucose, cardiovascular risk, quality of life, incident diabetes complications · 10 years
- Did not differ significantly between groups
Original publication
Long‐term impact of weight loss for people with overweight but not obesity, and with type 2 diabetes: 10‐year outcomes of a randomized trial of gastric band surgery. Diabetes Obes Metab. Published 14 February 2023. doi:10.
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