Liraglutide and Weight Loss Among Suboptimal Responders to Metabolic Bariatric Surgery: A Randomized Clinical Trial
Primary result · Weight changeResult — go to the resultBetween-group difference 7.1 kg 95% CI 3.9–10.3Authors' conclusion
In this randomized clinical trial, liraglutide provided greater weight loss at 12 months than placebo in a cohort of patients with a suboptimal response to MBS. These results suggest that combining obesity management medications with MBS affords the opportunity to increase weight loss for those with a suboptimal initial response or weight regain, potentially avoiding conversion surgery.
Study context
- Population
- Adults aged 20–65 years with suboptimal, stable weight loss 12–36 months after metabolic bariatric surgery (MBS) (adjustable gastric band, SG, one anastomosis gastric bypass or RYGB), BMI >35; academic surgical department
- Participants
- 24 vs 24
- Comparison
- Daily liraglutide vs placebo
- Liraglutiden = 24
- Placebon = 24reference
- Primary endpoint
- Weight loss
- Follow-up
- 12 months
Methodological detailsprospective, double-blinded, single-center, First participant randomized January 18, 2019; last June 9, 2023
- Prospective
- Double-blinded
- Single-center
- First participant randomized January 18, 2019; last June 9, 2023
Primary result
Weight change
Between-group difference
7.1 kg
95% CI 3.9–10.3
P < 0.001
Change by group
Liraglutide
5.7
mean · SE 1.1 · kg
Placebo
1.4
mean · SD 1.2 · kg
Liraglutidevs Placebo
between-group difference 7.1 kg (95% CI 3.9–10.3); P < 0.001
As reported in the abstract
Further findings
Withdrawals and loss to follow-up
- Liraglutide: withdrew
- 4
- Liraglutide: lost to follow-up
- 1
- Placebo: withdrew
- 6
- Placebo: lost to follow-up
- 6
Safety
- No adverse effects on health or quality of life
Original publication
Liraglutide and Weight Loss Among Suboptimal Responders to Metabolic Bariatric Surgery: A Randomized Clinical Trial. JAMA Netw Open. Published 1 October 2025. doi:10.
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