Gestational diabetes & diabetes in pregnancy
Long-Term Impact on Offspring (5 to 11 Years of Age) of Metformin Use in Pregnancy in Mothers With Diabetes: A Systematic Review and Meta-Analysis
Pooled result · Child BMIResult — go to the resultMD 1.09 kg/m² 95% CI −0.44 to 2.62Authors' conclusion
Metformin use in pregnancy did not show any adverse effects compared with insulin on long-term outcomes in children and their mothers.
Study context
- Population
- Mothers with GDM/diabetes in pregnancy and their children aged 5 to 11 years
- Comparison
- Metformin vs insulin for GDM/diabetes in pregnancy
- Outcome
- Change in BMI in children
- Follow-up
- Ages of 5 to 11 years
Pooled result
Child BMI · age 9 years
MD
1.09 kg/m²
95% CI −0.44 to 2.62
P = 0.16
Metforminvs Insulin
MD 1.09 kg/m² (95% CI −0.44 to 2.62); P = 0.16
As reported in the abstract
Further pooled results
| Outcome | MD (95% CI) | P value | |
|---|---|---|---|
| Child waist circumference-to-height ratio · age 9 yearsI2 = 94% | 0.13 (−0.05 to 0.30) | P = 0.16 | |
| −0.200.20.4Difference (linear scale) |
| Outcome | MD (kg) (95% CI) | P value | |
|---|---|---|---|
| Child DXA total fat mass · age 9 yearsI2 = 70% | 0.68 (−2.39 to 3.79) | P = 0.66 | |
| Child DXA total fat-free mass · age 9 yearsI2 = 55% | 0.81 (−0.96 to 2.58) | P = 0.37 | |
| −4−2024Difference, kg (linear scale) |
| Outcome | MD (%) (95% CI) | P value | |
|---|---|---|---|
| Child DXA total fat percent · age 9 yearsI2 = 56% | 0.04 (−3.44 to 3.51) | P = 0.98 | |
| Child magnetic resonance spectroscopy liver fat percentage · age 9 yearsI2 = 0% | 0.27 (−1.26 to 1.79) | P = 0.73 | |
| −4−2024Difference, % (linear scale) |
| Outcome | MD (cm³) (95% CI) | P value | |
|---|---|---|---|
| Child MRI visceral adipose tissue volume · age 9 yearsI2 = 78% | 80.97 (−136.47 to 298.41) | P = 0.47 | |
| −2000200400Difference, cm³ (linear scale) |
Child serum adiponectin, leptin, alanine aminotransferase and ferritin
- Comparable among groups
Child obesity, diabetes, motor and social development · ages 9 to 11 years
- Comparable between the 2 groups
Maternal body mass index (BMI) and risk of diabetes · after 9 years of childbirth
- Similar between the 2 groups of women
Original publication
Long-Term Impact on Offspring (5 to 11 Years of Age) of Metformin Use in Pregnancy in Mothers With Diabetes: A Systematic Review and Meta-Analysis. Endocr Pract. Published 12 June 2024. doi:10.
Composed by AI from the published abstract and checked against it. How Briefs are made →