Long-Term Glycemic Benefits and User Interaction Insights: Real-World Outcomes of Automated Insulin Delivery Use in a Pediatric Population
Authors' conclusion
Glycemic outcomes improved 12 months after AID initiation and were positively associated with the number of meal announcements and daily carbohydrates registered in the pump. User-initiated bolus insulin and percentage of active CGM wear time had no impact on AID performance.
Study context
- Population
- Pediatric individuals initiating automated insulin delivery (AID) (Tandem Control-IQ or MiniMedTM 780G)
- Participants
- 156 individuals
- Exposure
- Baseline vs 12 months after AID initiation
- Outcome
- Glycemic outcomes (TIR 3.9-10.0 mmol/L)
- Follow-up
- A year following AID initiation
Methodological detailsreal-world data
- Real-world data
Main finding
As reported in the abstract
P < 0.001
Observational data: associations, not effects.
Further findings
Individuals reaching target (TIR >70%) · baseline, month 1, month 12 · declined after an initial increase
P < 0.005
Active CGM wear time · month 12 · longer
P = 0.011
User-initiated insulin boluses (% of TDD) · month 12
P = 0.034
Carbohydrate intake relative to body weight · month 12 · reduced
P = 0.004
- Individuals reaching target (TIR >70%): Month 1 60.0%
Association of TIR with daily registered meals and carbohydrates (multivariate, adjusted for pump settings and total daily insulin dose)
- Positive association between TIR and daily registered meals
- P < 0.001
- Positive association between TIR and daily registered carbohydrates
- P = 0.003
Original publication
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