Long-term effects of blood pressure 130–139/80–89 mmHg on all-cause and cardiovascular mortality among Chinese adults with different glucose metabolism
Authors' conclusion
BP of 130-139/80-89 mmHg may lead to a significantly higher risk of all-cause and cardiovascular mortality in Chinese adults with diabetes, but not in those with normoglycemia or prediabetes. This suggests that the targeted BP for people with diabetes should be < 130-139/80-89 mmHg.
Study context
- Population
- Chinese adults in Shanghai with different glucose metabolism (normoglycemia, prediabetes, DM), cohort established 20022,004 analysed
- Participants
- 2,132 adults
- Exposure
- Blood pressure (BP) categories combined with glucose categories
- Outcome
- All-cause and cardiovascular mortality
- Follow-up
- 21 years
Methodological details21-year follow-up, multiple Cox regression
- 21-year follow-up
- Multiple Cox regression
Main finding
As reported in the abstract
All-cause and cardiovascular mortality by BP and glucose category (reference: BP < 130/80 mmHg and normoglycemia)
Estimate (95% CI)P value
130-139/80-89 mmHg, diabetesvs BP < 130/80 mmHg, normoglycemia
HR (all-cause mortality) 3.30(1.48–7.38)
P < 0.01130-139/80-89 mmHg, diabetesvs BP < 130/80 mmHg, normoglycemia
HR (cardiovascular mortality) 9.60(1.93–47.7)
P < 0.01Observational data: associations, not effects.
Further findings
| Outcome | BP < 130/80 mmHg | 130-139/80-89 mmHg | ≥ 140/90 mmHg or treated |
|---|---|---|---|
| Incidence of all-cause and cardiovascular mortality per 1,000 person-years | 4.5 and 1.3 per 1,000 person-years | 7.7 and 2.9 per 1,000 person-years | 19.9 and 8.7 per 1,000 person-years |
| All-cause | 4.5 | 7.7 | 19.9 |
| Cardiovascular | 1.3 | 2.9 | 8.7 |
- Incidence of all-cause and cardiovascular mortality per 1,000 person-years — Deaths: all-cause
- 397
- Incidence of all-cause and cardiovascular mortality per 1,000 person-years — Deaths: cardiovascular
- 166
Original publication
Long-term effects of blood pressure 130–139/80–89 mmHg on all-cause and cardiovascular mortality among Chinese adults with different glucose metabolism. Cardiovasc Diabetol. Published 21 December 2023. doi:10.
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