Loading Enhances Glucose Uptake in Muscles, Bones, and Bone Marrow of Lower Extremities in Humans
Authors' conclusion
Increased weight-bearing loading enhances GU in muscles, cortical bone, and bone marrow of the exposed lower extremities. This could be interpreted as increased local energy demand in bone and muscle caused by increased loading. The physiological importance of the increased local GU by static loading remains to be determined.
Study context
- Population
- Men with BMI between 30 and 35 kg/m²crossover
- Participants
- 10 men
- Comparison
- High load vs no load
- Primary endpoint
- Change in GU ratio between loaded bones (femur and tibia) and nonloaded bones (humerus), measured by whole-body quantitative PET/CT
Methodological detailssingle-centre, randomized crossover
- Single-centre
- Randomized crossover
Primary result
As reported in the abstract
GU ratio, loaded vs nonloaded bone (cortical diaphyseal bone)
Femur/humerus glucose uptake (GU) ratio increased with high load
19%
P = .029
Further findings
GU ratio in muscles
- M. quadriceps femoris/m. triceps brachii GU ratio increased with high load
- 28%, P = .014
GU ratio in bone marrow
- Femur/humerus diaphyseal bone marrow region GU ratio increased with high load
- 17%, P = .041
- Highest GU in bone marrow region of vertebral bodies, not affected by high load
Original publication
Loading Enhances Glucose Uptake in Muscles, Bones, and Bone Marrow of Lower Extremities in Humans. J Clin Endocrinol Metab. Published 16 May 2024. doi:10.
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