Synergy of Nodal Factors in Predicting Recurrence After Treatment of N1b Papillary Thyroid Carcinoma
Authors' conclusion
Nodal factors have synergistic effect in predicting recurrence in cN1b PTC patients. Increasing lymph nodes harvest may only decrease recurrence in patients without gENE, while not in gENE patients.
Study context
- Population
- Patients who underwent surgery for clinical N1b papillary thyroid carcinoma (PTC), 2013 to 2017
- Participants
- 1,067 patients
- Exposure
- Nodal factors and their interaction in predicting recurrence
- Outcome
- All site and nodal recurrence
Main finding
As reported in the abstract
- Largest dimension >3 cm, all site recurrence, HR
- 2.58 (1.67-4.00) (95% CI)
- gENE, all site recurrence, HR
- 1.87 (1.26-3.01) (95% CI)
- LNR >0.21, all site recurrence, HR
- 1.68 (1.11-2.42); all P < .01 (95% CI)
- Largest dimension >3 cm, nodal recurrence, HR
- 2.63 (1.67-4.13) (95% CI)
- gENE, nodal recurrence, HR
- 1.90 (1.15-3.12) (95% CI)
- LNR >0.21, nodal recurrence, HR
- 1.76 (1.17-2.66); all P < .01 (95% CI)
- LNR × gENE interaction, all site recurrence
- P for interaction = .009
- LNR × gENE interaction, nodal recurrence
- P for interaction = .02
Observational data: associations, not effects.
Further findings
LNR and recurrence, stratified by gENE
- Without gENE: LNR, all site recurrence, HR
- 2.41 (1.50-3.87) (95% CI)
- Without gENE: LNR, nodal recurrence, HR
- 2.51 (1.52-4.14); all P < .001 (95% CI)
- With gENE: LNR, all site recurrence, HR
- 0.81 (0.43-1.54), P = .53 (95% CI)
- With gENE: LNR, nodal recurrence, HR
- 0.85 (0.43-1.67), P = .64 (95% CI)
Original publication
Synergy of Nodal Factors in Predicting Recurrence After Treatment of N1b Papillary Thyroid Carcinoma. J Clin Endocrinol Metab. Published 15 May 2024. doi:10.
Composed by AI from the published abstract and checked against it. How Briefs are made →