Normative Data for Insulin-Like Growth Factor 1 in Healthy Children and Adolescents From India
Authors' conclusion
This study provides ethnicity-specific normative data on serum IGF-1 and will improve the diagnostic utility of IGF-1 in the evaluation and management of growth disorders in Indian children and adolescents.
Study context
- Population
- Apparently healthy Indian children and adolescents, recruited in schools and the community, robust exclusion criteria1,948 analysed
- Participants
- 2,226 children
- Exposure
- Girls vs Boys
- Girlsn = 942
- Boysn = 1,006
- Outcome
- Serum IGF-1 by electro-chemiluminescence immunoassay (ECLIA); CA-, BA- and Tanner stage-specific centiles (2.5th–97.5th) by generalized additive models
Methodological detailsepidemiological, schools and community
- Epidemiological
- Schools and community
Main finding
As reported in the abstract
Median IGF-1 peak
- Girls: peak at chronological age (CA) 13 years
- 321.7 ng/mL
- Girls: peak at bone age (BA) 14 years
- 350.2 ng/mL
- Girls: peak at Tanner stage IV
- 345 ng/mL
- Boys: peak at CA 15 years
- 318.9 ng/mL
- Boys: peak at BA 15 years
- 340.6 ng/mL
- Boys: peak at Tanner stage III
- 304.8 ng/mL
Observational data: associations, not effects.
Further findings
Reference interval (2.5th to 97.5th percentile)
- Broader during peripubertal ages, indicating higher physiological variability
Original publication
Normative Data for Insulin-Like Growth Factor 1 in Healthy Children and Adolescents From India. J Clin Endocrinol Metab. Published 15 May 2024. doi:10.
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