Adding Letrozole to Growth Hormone and Gonadotropin-Releasing Hormone Analog Increases Height in Girls With Short Stature: A Hospital Record–Based Retrospective Study
Main finding · ΔPAHResult — go to the resultDifference 4 cmAuthors' conclusion
Combined treatment with GH, GnRHa, and letrozole can enhance the adult height and PAH in short-statured girls, and no significant side effects have been reported.
Study context
- Population
- Girls with short stature and advanced bone age; mean age 11.17 years (treatment) and 12.43 years (control)
- Participants
- 29 vs 29
- Exposure
- Recombinant human growth hormone (rhGH) + GnRHa + letrozole vs rhGH/GnRHa
- Treatmentn = 29
- Controln = 29reference
- Outcome
- ΔPAH
Methodological detailshospital record-based, Mean treatment duration 17.31 months (treatment) and 16.59 months (control)
- Hospital record-based
- Mean treatment duration 17.31 months (treatment) and 16.59 months (control)
Main finding
As reported in the abstract
Difference
4 cm
P < 0.001
Change by group
Treatment
5.85
cm
Control
1.82
cm
Observational data: associations, not effects.
Further findings
PAH before vs after treatment (Treatment)
- PAH before vs after treatment, cm
- 155.38 vs 161.32; P < .001
Height SDS for bone age and chronological age, before vs after treatment
- Significant difference in height SDS for bone age
- P < 0.001
- Significant difference in height SDS for chronological age
- P = 0.003
Height gain and growth rate
- Height gain
- 8.71 ± 4.46 cm
- Growth rate
- 6.78 ± 3.84 cm per year
Safety
- Increasing BMI during therapy
- P = 0.039
Original publication
Adding Letrozole to Growth Hormone and Gonadotropin-Releasing Hormone Analog Increases Height in Girls With Short Stature: A Hospital Record–Based Retrospective Study. Endocr Pract. Published 7 May 2024. doi:10.
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