Adult Height in Girls with Central Precocious Puberty with Onset after 6 Years: Effects of Gonadotropin-Releasing Hormone Analog Therapy
Authors' conclusion
GnRHa therapy was effective in improving the AH in girls with CPP onset at the age of 6, 7, or 8 years. The TH was a strong determinant of the AH.
Study context
- Population
- Girls aged ≥6 years meeting the Japanese diagnostic criteria for precocious puberty (PP), 7 study centres, April 2000–March 2020
- Participants
- 133 participants
- Exposure
- Gonadotropin-releasing hormone analog (GnRHa) therapy vs no treatment
- Treatmentn = 56
- No-treatmentn = 77reference
- Outcome
- Adult height (AH) and target height (TH)
Methodological detailsmulticentre
- Multicentre
Main finding
As reported in the abstract
AH, AH - TH and predicted AH in girls aged 6, 7 and 8 years (6 ≤ years < 9)
- GnRHa-treated girls achieved significantly greater increase in adult height (AH), AH - target height (TH) and predicted AH at age 6, 7 and 8 years than untreated girls
- Treatment vs No-treatment: significantly greater increase with treatment
Observational data: associations, not effects.
Further findings
Factors influencing AH in Treatment
- TH and height at start and end of treatment influenced AH of treated girls
Original publication
Adult Height in Girls with Central Precocious Puberty with Onset after 6 Years: Effects of Gonadotropin-Releasing Hormone Analog Therapy. Horm Res Paediatr. Published 21 November 2024. doi:10.
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