Lifetime and 10‐year cardiovascular risk prediction in individuals with type 1 diabetes: The LIFE‐T1D model
Authors' conclusion
The LIFE-T1D model can estimate lifetime risk of CVD and CVD-free life expectancy in individuals with type 1 diabetes without previous CVD. This model can facilitate individualized CVD prevention among individuals with type 1 diabetes. Validation in additional cohorts will improve future clinical implementation.
Study context
- Population
- Individuals with T1D without prior cardiovascular disease (CVD)
- Participants
- 39,756 / 2,709 / 1,022
- Comparison
- National Diabetes Register (NDR) vs Funen Diabetes Database (FDDB) vs UK Biobank
- NDRn = 39,756
- FDDBn = 2,709
- UK Biobankn = 1,022
- Outcome
- Lifetime and 10-year risk of CVD (model discrimination, c-statistic)
Methodological detailssex-specific competing risk-adjusted Cox proportional hazards model, age as the time axis
- Sex-specific competing risk-adjusted Cox proportional hazards model
- Age as the time axis
Performance
As reported in the abstract
C-statistic
| Test or model | Value | Internal validation c-statistic | External validation c-statistic |
|---|---|---|---|
| NDR | 0.85 (95% CI 0.84–0.85) | 0.85 | |
| FDDB | 0.77 (95% CI 0.74–0.81) | 0.77 | |
| UK Biobank | 0.73 (95% CI 0.70–0.77) | 0.73 |
Value
NDR0.85 (95% CI 0.84–0.85)
FDDB0.77 (95% CI 0.74–0.81)
UK Biobank0.73 (95% CI 0.70–0.77)
Internal validation c-statistic
NDR0.85
FDDB— not stated in the abstract
UK Biobank— not stated in the abstract
External validation c-statistic
NDR— not stated in the abstract
FDDB0.77
UK Biobank0.73
Further findings
Events in NDR · median follow-up 11.8 years (IQR 6.1-17.1 years)
- CVD events
- 4608
- Non-CVD deaths
- 1316
Parts of this Brief are withheld: the automatic checks could not confirm them against the abstract.
Original publication
Lifetime and 10‐year cardiovascular risk prediction in individuals with type 1 diabetes: The LIFE‐T1D model. Diabetes Obes Metab. Published 8 March 2024. doi:10.
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