Evaluation of a Protocol Change Promoting Lactated Ringers Over Normal Saline in the Treatment of Diabetic Ketoacidosis
Authors' conclusion
In this retrospective cohort study, protocolized DKA intravenous fluid management with LR resulted in shorter time to resolution of DKA and reduced duration of DKA protocol insulin drip.
Study context
- Population
- Adults admitted with diabetic ketoacidosis (DKA) before and after a protocol change at a single institution
- Participants
- 246 adults
- Exposure
- LR vs normal saline (NS) as default DKA resuscitative and maintenance fluid
- LRn = 127
- NSn = 119reference
- Outcome
- Time from DKA clinical presentation until DKA resolution
Methodological detailssingle institution, before-and-after protocol change
- Single institution
- Before-and-after protocol change
Main finding
As reported in the abstract
Time to DKA resolution
P = 0.02
Observational data: associations, not effects.
Secondary outcomes
Duration of DKA protocol insulin drip · shorter with LR
P < 0.001
Original publication
Evaluation of a Protocol Change Promoting Lactated Ringers Over Normal Saline in the Treatment of Diabetic Ketoacidosis. J Diabetes Sci Technol. Published 7 March 2024. doi:10.
Composed by AI from the published abstract and checked against it. How Briefs are made →