Evaluation of Glucose Metrics in Adults with Type 1 Diabetes Switching to Insulin Glargine 300 U/mL: A Retrospective, Propensity-Score Matched Study
Authors' conclusion
In real-life, Gla-300 was typically initiated in people where TIR was decreasing, which was reversed after switch using slightly higher basal insulin dose.
Study context
- Population
- Adults with T1D, real-world settingmatched controls
- Participants
- 151 vs 281
- Exposure
- Switch to insulin glargine 300 U/mL (Gla-300) vs continued first-generation long-acting insulins
- Switchersn = 151
- Non-switchersn = 281reference
- Outcome
- Difference in TIR evolution
Methodological detailspropensity-score matched, secondary-use
- Propensity-score matched
- Secondary-use
Main finding
As reported in the abstract
TIR evolution after Gla-300 initiation · after switch
- After Gla-300 initiation, Switchers had similar time in range (TIR) increase vs Non-switchers
- Switchers vs Non-switchers: P = 0.531
Observational data: associations, not effects.
Further findings
| Outcome | P value |
|---|---|
| TIR trend before switching · period before switching | between-group difference P = 0.047 |
- TIR trend before switching — TIR decreased numerically in people in whom Gla-300 was eventually initiated
- −0.05%/month [−0.16 to 0.07]
- TIR trend before switching — TIR increased in matched controls
- 0.08%/month [0.02 to 0.015]
Basal insulin dose in Switchers, after vs before switch
- Switchers used higher basal dose than before switch (Δ, U/[kg·d])
- 0.012 [0.006 to 0.018]; P < 0.0001
Original publication
Evaluation of Glucose Metrics in Adults with Type 1 Diabetes Switching to Insulin Glargine 300 U/mL: A Retrospective, Propensity-Score Matched Study. Diabetes Technol Ther. Published 6 March 2024. doi:10.
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