Life expectancy associated with different ages at diagnosis of type 2 diabetes in high-income countries: 23 million person-years of observation
Authors' conclusion
Every decade of earlier diagnosis of diabetes was associated with about 3-4 years of lower life expectancy, highlighting the need to develop and implement interventions that prevent or delay the onset of diabetes and to intensify the treatment of risk factors among young adults diagnosed with diabetes.
Study context
- Population
- Participants from 19 high-income countries in the Emerging Risk Factors Collaboration and UK Biobank; 23.1 million person-years of follow-up96 cohorts + UK Biobank
- Participants
- 1,515,718 participants
- Exposure
- Age at diagnosis of diabetes vs no diabetes
- Outcome
- All-cause mortality according to age at diagnosis of diabetes (age- and sex-adjusted HRs)
Methodological details19 high-income countries, Emerging Risk Factors Collaboration (96 cohorts) and UK Biobank
- 19 high-income countries
- Emerging Risk Factors Collaboration (96 cohorts) and UK Biobank
Main finding
As reported in the abstract
All-cause mortality
Each group vs no diabetesHazard ratio (95% CI)
Diagnosed 30-39 years
2.69(2.43–2.97)
Diagnosed 40-49 years
2.26(2.08–2.45)
Diagnosed 50-59 years
1.84(1.72–1.97)
Diagnosed 60-69 years
1.57(1.47–1.67)
Diagnosed ≥70 years
1.39(1.29–1.51)
Observational data: associations, not effects.
Further findings
Hazard ratios (HRs) per decade of earlier diagnosis by sex
- HRs per decade of earlier diagnosis similar for men and women
Years of life lost for a 50-year-old with diabetes vs without, USA death rates
Years earlier
- Diagnosed aged 30 years
- 14
- Diagnosed aged 40 years
- 10
- Diagnosed aged 50 years
- 6
Years of life lost for a 50-year-old with diabetes vs without, EU death rates
Years earlier
- Diagnosed aged 30 years
- 13
- Diagnosed aged 40 years
- 9
- Diagnosed aged 50 years
- 5
Original publication
Life expectancy associated with different ages at diagnosis of type 2 diabetes in high-income countries: 23 million person-years of observation. Lancet Diabetes Endocrinol. Published 11 September 2023. doi:10.
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