L ow‐density lipoprotein cholesterol and non‐high‐density lipoprotein cholesterol in type 1 diabetes and type 2 diabetes: Lipid goal attainment in a large German–Austrian diabetes registry
Authors' conclusion
Approximately 2 years after publication of the guidelines, LDL-C and non-HDL-C goal attainment was rarely achieved in patients with T1D and T2D with a high or very high cardiovascular risk.
Study context
- Population
- Adults with T1D or T2D in a German and Austrian registry, 2020 and 2021, stratified by 2019 European Society of Cardiology (ESC)/European Atherosclerosis Society (EAS) risk categories
- Participants
- 32,170 adults
- Exposure
- T1D vs T2D
- T1Dn = 8,314
- T2Dn = 23,856
- Outcome
- Guideline-based LDL-C and non-HDL-C goal attainment by risk category
Methodological detailsGerman–Austrian diabetes registry
- German–Austrian diabetes registry
Main finding
As reported in the abstract
LDL-C goal attainment by risk category
- T1D, very high risk: Low-density lipoprotein cholesterol (LDL-C) <55 mg/dL
- 6.16%
- T1D, high risk: LDL-C <70 mg/dL
- 10.97%
- T1D, moderate risk: LDL-C <100 mg/dL
- 69.50%
- T2D, very high risk: LDL-C <55 mg/dL
- 11.81%
- T2D, high risk: LDL-C <70 mg/dL
- 16.25%
- T2D, moderate risk: LDL-C <100 mg/dL
- 51.33%
Observational data: associations, not effects.
Further findings
Age · spread printed in brackets without its kind named
Non-HDL-C goal attainment by risk category
- T1D, very high risk
- 15.3%
- T1D, high risk
- 25.52%
- T1D, moderate risk
- 91.61%
- T2D, very high risk
- 18.56%
- T2D, high risk
- 17.96%
- T2D, moderate risk
- 82.30%
- Non-HDL-C goals reached more often than LDL-C goals
Lipid-lowering therapy use
- T1D: statin
- 19.3%
- T1D: ezetimibe
- 2.2%
- T1D: PCSK9 inhibitors or fibrates
- less than 1%
- T2D: statins
- 45.7%
- T2D: ezetimibe
- 3.4%
- T2D: fibrates
- 1%
- T2D: PCSK9 inhibitors
- 0.1%
Original publication
L ow‐density lipoprotein cholesterol and non‐high‐density lipoprotein cholesterol in type 1 diabetes and type 2 diabetes: Lipid goal attainment in a large German–Austrian diabetes registry. Diabetes Obes Metab. Published 11 September 2023. doi:10.
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