Leptin receptor expression in blood mononuclear cells of lactating women is associated with infant body weight: Potential role as a molecular biomarker
Authors' conclusion
LEPR and SOCS3 gene expression in PBMCs are novel maternal molecular biomarkers that reflect leptin resistance and are associated with infant body weight and adiposity.
Study context
- Population
- Lactating women at day 10 postpartum and their infants
- Participants
- 68 women
- Outcome
- Maternal PBMC gene expression and infant body weight
Main finding
As reported in the abstract
Leptin receptor (LEPR) expression vs infant weight z-score, Beta (95% CI 0.17, 0.63), p = 0.001
0.40
SOCS3 expression vs infant weight z-score, Beta (95% CI 0.04, 0.51), p = 0.024
0.28
SOCS3 expression vs infant arm circumference, Beta (95% CI 0.32, 0.82), p < 0.001
0.57
Observational data: associations, not effects.
Further findings
Mothers with pre-pregnancy overweight or obesity (OW/OB)
- LEPR expression reduced, p = 0.013
- Plasma and milk leptin and milk insulin concentrations elevated
Original publication
Leptin receptor expression in blood mononuclear cells of lactating women is associated with infant body weight: Potential role as a molecular biomarker. Pediatr Obes. Published 31 August 2023. doi:10.
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