Leptin Increase During Dexamethasone and Its Association With Hunger and Fat in Pediatric Acute Lymphoblastic Leukemia
Authors' conclusion
Five days of high-dose dexamethasone treatment led to direct and significant changes in leptin, hunger scores, and fat mass. Since children with ALL are at increased risk for metabolic adverse events, understanding underlying mechanisms is important, and a dexamethasone-induced state of acute leptin resistance might play a role.
Study context
- Population
- Pediatric acute lymphoblastic leukemia (ALL) patients during maintenance treatment; median age 5.4 years (range, 3.0–18.8)
- Participants
- 105 patients
- Exposure
- Before vs after a 5-day dexamethasone course
- Outcome
- Changes in leptin, fat mass, BMI, hunger, sleep and fatigue
- Follow-up
- After 5-day dexamethasone course
Methodological detailsbefore-after (T1 vs T2) design, paired tests
- Before-after (T1 vs T2) design
- Paired tests
Main finding
As reported in the abstract
Changes in leptin, fat mass, BMI, hunger, fatigue and sleep · after 5 days of dexamethasone
- Leptin, fat mass, hunger scores, fatigue and sleep deteriorated after 5 days of dexamethasone
- P < .001
- BMI did not change significantly
- P = .12
Observational data: associations, not effects.
Further findings
Correlations between delta leptin and delta fat mass, BMI, hunger, fatigue or sleep
- No correlations found
Factors associated with elevated leptin at T1
- Older age, OR
- 1.51 (1.28-1.77) (95% CI)
- Higher fat mass, OR
- 1.19 (1.07-1.33) (95% CI)
- Earlier maintenance week, OR
- 0.96 (0.92-0.99) (95% CI)
- Univariable regression
Original publication
Leptin Increase During Dexamethasone and Its Association With Hunger and Fat in Pediatric Acute Lymphoblastic Leukemia. J Clin Endocrinol Metab. Published 25 October 2023. doi:10.
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