Lean body mass but not body fat mass is related with leukocyte telomere length in children
Authors' conclusion
Skeletal muscle mass and bone mass but not body fat content or distribution were significantly associated with LTL in this pediatric population.
Study context
- Population
- Healthy Chinese children aged 6–11 years175 girls · 231 boys
- Participants
- 406 children
- Outcome
- Association between body composition (DXA: fat content and distribution, ASM, ASMI, BMD, BMC, TBLM) and relative LTL (quantitative PCR)
Main finding
As reported in the abstract
Body fat content or regional fat distribution: not significantly associated with leukocyte telomere length (LTL)
β = −8.48 × 10-6-1.44 × 10-1
p = 0.227-0.959
ASM, ASM/height2 (ASMI), total body (TB) bone mineral content (BMC)/TB bone mineral density (BMD), total body less head (TBLH) BMC/TBLH BMD and total body lean mass (TBLM): positively associated with LTL
β = 8.95 × 10-6-4.95 × 10-1
p = 0.005-0.035
Observational data: associations, not effects.
Further findings
Dose-dependent association of LTL with ASM, TB BMC/BMD, TBLH BMC/BMD and TBLM (analysis of covariance)
- Significant dose-dependent positive association
- P for trend = 0.002-0.025
Original publication
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