Ketone Body Infusion Abrogates Growth Hormone–Induced Lipolysis and Insulin Resistance
Authors' conclusion
Our data unravel an insulin-sensitizing effect of βOHB, which we suggest is mediated by concomitant suppression of lipolysis.
Study context
- Population
- Healthy men; Growth hormone (GH) infusion to induce lipolysiscrossover
- Participants
- 8 men
- Comparison
- βOHB infusion vs saline during GH infusion
- βOHBn = 8
- Salinen = 8reference
- Primary endpoint
- Insulin sensitivity (hyperinsulinemic-euglycemic clamp with glucose tracer)
Methodological detailssingle-blinded, Each study day: basal period and hyperinsulinemic-euglycemic clamp with glucose tracer, adipose tissue and skeletal muscle biopsies
- Single-blinded
- Each study day: basal period and hyperinsulinemic-euglycemic clamp with glucose tracer, adipose tissue and skeletal muscle biopsies
Primary result
As reported in the abstract
- βOHB profoundly suppressed free fatty acid (FFA) levels
- Significant increase in glucose disposal with βOHB
- Significant increase in energy expenditure with βOHB
Further findings
- Many-fold increase in skeletal muscle content of βOHB and acetoacetate
Original publication
Ketone Body Infusion Abrogates Growth Hormone–Induced Lipolysis and Insulin Resistance. J Clin Endocrinol Metab. Published 14 October 2022. doi:10.
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