Joint association of triglyceride-glucose (TyG) index and high sensitivity C-reactive protein with cardiovascular disease: a national cohort study
Main finding · Overall CVDResult — go to the resultAdjusted hazard ratio 1.300 95% CI 1.155–1.462Authors' conclusion
The findings highlight the coexposure effects and mutual mediation between the TyG index and hsCRP on cardiovascular diseases. Joint assessments of the TyG index and hsCRP should be underlined for the residual risk stratification and primary prevention of cardiovascular diseases, especially for middle-aged adults.
Study context
- Population
- Adults aged ≥45 years free of CVD at baseline, China Health and Retirement Longitudinal Study (CHARLS) 2011, China; mean age 58.6 ± 9.0 years, 46.1% female
- Participants
- 8,658 adults
- Exposure
- Higher TyG index and higher high-sensitivity C-reactive protein (hsCRP) vs lower TyG index and hsCRP <1 mg/L
- Outcome
- Cardiovascular events: physician-diagnosed heart disease and/or stroke
- Follow-up
- Followed until 2018; maximum 7.0 years
Methodological detailsnationally representative, longitudinal, adjusted Cox proportional hazards regression, mediation analyses
- Nationally representative
- Longitudinal
- Adjusted Cox proportional hazards regression
- Mediation analyses
Main finding
Overall CVD
Adjusted hazard ratio
1.300
95% CI 1.155–1.462
High TyG + high hsCRPvs Low TyG + hsCRP <1 mg/L
aHR 1.300 (95% CI 1.155–1.462)
As reported in the abstract
Observational data: associations, not effects.
Further findings
| Outcome | aHR (95% CI) | |
|---|---|---|
| Coronary heart diseaseHigh TyG + high hsCRPvs Low TyG + hsCRP <1 mg/L | 1.294 (1.130–1.481) | |
| StrokeHigh TyG + high hsCRPvs Low TyG + hsCRP <1 mg/L | 1.333 (1.093–1.628) | |
| 0.512Adjusted hazard ratio (log scale) |
Incident CVD (whole cohort) · maximum follow-up 7.0 years
- Developed CVD
- 2606 (30.1%)
- Heart disease cases
- 2012 (23.2%)
- Stroke cases
- 848 (9.8%)
Mutual mediation
- High hsCRP mediated share of TyG–CVD association
- 13.4%
- TyG mediated share of hsCRP–CVD association
- 7.9%
Original publication
Joint association of TyG index and high sensitivity C-reactive protein with cardiovascular disease: a national cohort study. Cardiovasc Diabetol. Published 7 May 2024. doi:10.
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