Insulin sensitivity estimates and their longitudinal association with coronary artery disease in type 1 diabetes. Does it matter?
Authors' conclusion
In type 1 diabetes, estimated glucose disposal rates are associated with subsequent coronary artery disease, modulated by kidney disease severity. Future research is merited regarding the clinical usefulness of estimating the glucose disposal rate as a coronary artery disease risk factor and potential therapeutic target.
Study context
- Population
- Adults with T1D in the FinnDiane Study, by baseline kidney status
- Participants
- 3,517 adults
- Exposure
- Three formulae estimating glucose disposal rate
- Outcome
- Incidence of coronary artery disease
- Follow-up
- Median (IQR) 19.3 (14.6, 21.4) years
Methodological detailsFinnDiane Study, longitudinal
- FinnDiane Study
- Longitudinal
Main finding
As reported in the abstract
Coronary artery disease event · median 19.3 years
Coronary artery disease event, with higher rates with worsening baseline kidney status
539
15.3%
Observational data: associations, not effects.
Original publication
Insulin sensitivity estimates and their longitudinal association with coronary artery disease in type 1 diabetes. Does it matter? Cardiovasc Diabetol. Published 3 May 2024. doi:10.
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